Influence of bisphosphonates in Implantology

Abstract

Bisphosphonates have been introduced into medical practice as drugs that inhibit osteodegenerative conditions such as Paget's disease, malignant hypercalcemia, and osteoporosis, as well as being used in the treatment of patients with metastatic solid tumors and multiple myeloma. These drugs are capable of altering bone remodeling, raising concerns about their impact on surgical procedures in the area of Implantology. There is a link between the use of bisphosphonates and the development of osteonecrosis of the jaw, a relatively recent condition that significantly disrupts quality of life due to exposure of necrotic bone and pain in the mandible and maxilla, causing considerable morbidity to the affected individual. The placement of dental implants in patients undergoing bisphosphonate therapy remains a debated topic. This paper seeks to examine the literature on the use of bisphosphonates in dentistry, particularly because they may serve as a potential alternative for reducing bone loss and enhancing bone density, while also considering the risk of osteonecrosis of the jaws, which necessitates therapeutic and preventive interventions.