Jaw osteonecrosis related to the use of denosumab

Abstract

This article examines contemporary literature on jaw osteonecrosis related to the use of denosumab, a medication that interferes with bone remodeling by inhibiting osteoclastogenesis. It discusses the stages of the condition, often associated with oral surgeries following pharmacological treatment. Symptoms such as deep bone pain and dental mobility are highlighted, emphasizing the importance of early diagnosis. Diagnostic methods, such as panoramic radiography and cone-beam computed tomography, are addressed, as well as the incidence of jaw osteonecrosis in patients treated with denosumab. Preventively, the need for dental treatment before the initiation of these drugs is emphasized. The literature covers treatment strategies, from medicinal approaches to surgical interventions, highlighting the importance of regular dental monitoring. It is concluded that a comprehensive understanding of jaw osteonecrosis related to denosumab by the dentist requires a multidisciplinary approach for effective diagnosis, prevention, and treatment.